MOTS-c

MOTS-c is a 16–amino-acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. It belongs to a class of short open-reading-frame–encoded peptides originating from mitochondrial DNA, and is supplied as a lyophilized powder for in-vitro research into mitochondrial signaling, AMPK-pathway biology, and cellular metabolic regulation.

Molecular Profile

• CAS Number1627580-64-6
• Molecular Weight2,174.5 g/mol
• Molecular FormulaC₁₀₁H₁₅₂N₂₈O₂₂S₂
• SequenceMRWQEMGYIFYPRKLR (16 aa)
• Purity≥99.7% (HPLC-MS/MS)
• FormatLyophilized white powder
• Storage−20°C, desiccated
• ReconstitutionSterile bacteriostatic water

Research Context

First characterized by Lee et al. (2015) as a mitochondrial-derived peptide that translocates to the nucleus under metabolic-stress conditions to regulate AMPK-dependent gene expression. In the preclinical literature it is used to investigate mitochondrial stress signaling, glucose and lipid metabolism, insulin-signaling models, and cellular energy homeostasis.

Quality Assurance

Every lot is independently tested for identity and purity by SideChain Analytics (HPLC-MS/MS), and a Certificate of Analysis is available for each batch. Produced and shipped from within Canada.

Available exclusively for in-vitro laboratory research. Not a drug, natural health product, or food; not for human or veterinary use, and not evaluated for diagnostic or therapeutic application. Researchers are responsible for compliance with all applicable regulations.

• CompoundMOTS-c
• Strength10 mg per vial
• Pack sizes1 vial · 3 pack · 6 pack
• AppearanceLyophilized white powder
• Storage−20°C, protect from light
• VerificationThird-party HPLC-MS/MS (SideChain Analytics)
• OriginNorth American made · ships from Canada

Reported in preclinical, in-vitro literature as a regulator of AMPK-dependent metabolic signaling. Common research areas include:

• Mitochondrial stress-response signaling
• Glucose and lipid metabolism pathways
• Insulin-signaling models
• Cellular energy and metabolic homeostasis

These are areas of laboratory investigation only. No physiological, clinical, or health outcome is claimed or implied for any use of this compound.

MOTS-c is translated from a short open reading frame within the mitochondrial 12S rRNA. Under metabolic stress, published research reports that it translocates from the cytosol to the nucleus and modulates AMPK-dependent gene expression, influencing pathways associated with cellular metabolism and mitochondrial homeostasis. This mechanism is described in the peer-reviewed literature and is provided for scientific reference only.